The first smaller combatant of the Navy known as the littoral combat ship (LCS) will be based in San Diego.
It will be interesting to see if basing moves west to Japan, Singapore, or Guam in the future. While the littorals in the Gulf region seem prime candidates for this ship, this region is not the only place the LCS could be valuable.
Right now, our ships are too high value to operate in the restricted waters of the Taiwan Strait. Despite some who see US warships lunging into the Taiwan Strait to shield Taiwan from a Chinese attack, we aren't putting our current ships in that constricted water during a war.
So the LCS would work nicely in the Taiwan Strait. Conventionally powered submarines would also work very well there if based close by.